EFFECTS OF ALTITUDE ANOXIA ON RENAL FUNCTION

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Abstract
Renal function studies were done on 5 dogs at ground level and at altitudes of 18,000 and 24,000 ft. Glomerular filtration rate, as detd. by the clearance of creatinine or clearance of inulin, was either increased, decreased, or unaffected by exposure of the animals to altitude. The effective renal plasma flow, as detd. by the clearance of p-amino-hippuric acid, was increased in all animals at 18,000 ft. and increased further in one but decreased in the other animals at 24,000 ft. The max. tubular excretory ability for p-amino-hippuric acid was markedly increased at 18,000 ft. in one animal and at 24,000 ft. in 2 animals, but unchanged in the other altitude studies.

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