Effect of Dietary Free Gossypol on Blood Components and Tissue Iron in Swine and Rats

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Abstract
Pigs were fed a diet that contained 0.06% free gossypol for 43 days. Before the pigs showed symptoms associated with gossypol toxicity, the hemoglobin and hematocrit were reduced. The serum iron-binding capacity and total serum protein were reduced by approximately 20% which was attributed to an effect of gossypol on protein synthesis. Also, the liver iron concentration was lower in the gossypol-fed pigs. The data indicated that gossypol may have formed a complex with iron in the liver and the gossypol-iron complex was secreted from that organ via the bile which decreased the liver iron concentration. In a 2 × 2 factorial rat experiment, there was an effect of gossypol which lowered the hemoglobin and hematocrit and an iron × gossypol interaction that reduced the liver iron concentration. It was found that the ratio of free to bound gossypol deposited in the liver is dependent on the liver iron concentration.

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