Pseudohypoparathyroidism with Osteitis Fibrosa Cystica and Impaired Absorption of Calcium

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Abstract
Studies are presented in a 41-year-old woman with pseudohypoparathyroidism in whom the radiologic and histologic changes of osteitis fibrosa cystica were found together with hypertrophy of 4 parathyroid glands. Impaired absorption of calcium was shown by balance study and by abnormally high fecal recovery of orally administered Ca47. Treatment with large doses of vitamin D increased calcium absorption and led to healing of the osteitis fibrosa. The possible relationship between the defect in calcium metabolism and the renal tubular resistance to parathyroid hormone is discussed.