DISTRIBUTION AND METABOLISM OF I131 LABELED HUMAN SERUM ALBUMIN IN CONGESTIVE HEART FAILURE WITH AND WITHOUT PROTEINURIA

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Abstract
The distribution and metabolism of I131 labeled human serum albumin were studied in 10 cardiac subjects with congestive heart failure and in 10 non-cardiac control subjects. Significant proteinuria was present in 5 of the cardiac and 2 of the non-cardiac patients. Total exchangeable albumin, the intravascular-extravascular partition of exchangeable albumin, and the rate of albumin synthesis were not significantly altered in patients with congestive heart failure. In 6 of 7 patients with proteinuria, the amount of albumin degraded was significantly less than in nonproteinuric subjects and the amount of protein synthesized was about the same as in subjects without proteinuria. A subject with myxedema but without proteinuria had the greatest quantity of exchangeable albumin, the largest extravascular fraction of total exchangeable albumin, and the lowest rate of albumin synthesis.

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