Serum Proteins in Aminopterin Treated Rats

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Abstract
Different fractions of serum proteins were determined by paper electrophoresis in folic acid-deficient and pair-fed normal rats. Total serum protein was low and plasma fibrinogen was significantly high in the deficient animals. There was a significant decrease in albumin and gamma globulin and a considerable increase in [alpha]2-globulin, with no significant change in the [alpha]-1- and [beta]-globulin fractions in the serum of folic acid-deficient rats.