Studies on scutellariae radix. III. Effects on lipid metabolism in serum, liver and fat cells of rats.

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Abstract
The effects of Scutellariae Radix (Ogon in Japanese) and its flavone components on lipid metabolism in the rat were investigated. Wogonon inhibited deposition of liver triglyceride and increased serum HDL[high density lipoprotein]-cholesterol level in rats fed on corn oil-cholesterol-sodium cholate mixture. Skullcapflavone II reduced the serum total cholesterol level and liver triglyceride content, and increased serum HDL-cholesterol. Baicalein and baicalin reduced the serum free fatty acid and triglyceride levels and liver triglyceride content. In addition to the in vivo experiments, the effects of flavone components of Ogon on lipid metabolism in fat cells isolated from epididymal adipose tissue of rats were examined. Wogonin and baicalein selectively inhibited adrenaline[epinephrine, E]-induced lipolysis, and baicalein and baicalin selectively activated ACTH-induced lipolysis in fat cells. Skullcap-flavone II inhibited E- and ACTH-inhibited lipolysis and lipogenesis fom glucose in fat cells.