Effect of Time on the Response to Cyanide Anoxia of Frog Heart Damaged by Isoproterenoi*)

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Abstract
Isoproterenol (IPR) induces damage to the heart of frogs [Rana pipiens] living at 25.degree. C. The resistance of an isometric ventricular strip to histotoxic anoxia induced by cyanide is significantly reduced 4 h after 1 injection of IPR and still more after repeated injections. Macroscopically visible heart lesions are observed only on the first 2 days after the 2nd injection of IPR. The response of the heart muscle preparation to cyanide is then continuously improved during 3-4 wk after IPR and the disturbance of the myocardial function is only temporary and may at least partly by induced by metabolites of the catecholamine.