STUDIES ON THE ADRENAL DURING SIMULTANEOUS ADMINISTRATION OF DDD AND AMPHENONE

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Abstract
IN 1948 Nelson and Woodard (1, 2) reported that oral administration of DDD (2,2-bis(parachlorophenyl)-1,1,dichloroethane) an analog of the common insecticide DDT, causes atrophy of the adrenal cortex and further that this atrophy is species specific for the dog. Several papers have since appeared dealing with the alterations of physiology induced by this compound but no data concerning the mechanism of action has been recorded apart from the postulation by one of us, J.N. (3), that the substance might act by “blocking” the effect of ACTH. A few reports indicate that the compound may have an effect in species other than the dog; these will be discussed later. Hertz et al. (4) have established that Amphenone causes cessation of function of the adrenal and subsequent engorgement of the cortical cells with cholesterol and hypertrophy.