Transient Apnea after an Enkephalin Analogue in the Preterm Rabbit

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Abstract
FK 33-824, a potent enkephalin analog, was administered systematically, 0.5-5 mg/kg, to preterm neonatal rabbits. A marked decrease in respiratory frequency, irregular breathing and apneic spells was recorded at 5 mg/kg. Tidal volume was not affected. The enkephalin-induced respiratory depression was restored immediately after naloxone (10 mg/kg). Brain stem enkephalin neurons may be involved in the pathogenesis of neonatal transient apnea and irregular breathing.