Inheritable and Congenital Hyperbilirubinemia
- 16 December 1971
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 285 (25) , 1416-1421
- https://doi.org/10.1056/nejm197112162852507
Abstract
BILIRUBIN is an orange organic anion and a catabolic product of heme degradation that does neither any good nor any harm except to a few unfortunate newborn infants whose nervous systems seem to be uniquely susceptible to neuronal damage by bile pigment. Abnormalities affecting the formation, distribution and removal of bile pigment in man are manifested by a yellow color of the skin and scleras that has attracted the interest of physicians and patients since antiquity. Inheritable abnormalities in any one of these areas usually result in hyperbilirubinemia, which is an easily recognized phenotypic manifestation. As a result, it is . . .Keywords
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