Ros‐mediated activation of NF‐κB and Foxo during muscle disuse

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Abstract
We examined reactive oxygen species as upstream activators of nuclear factor κB; (NF‐κB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization‐induced transactivation of both NF‐κB and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy. Muscle Nerve, 2010
Funding Information
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R03AR056418)