Studies on the Therapeutic Resistance of Cutaneous Leishmania Infections

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Abstract
The chemotherapeutic study of Leishmania leproide (L. brasiliensis pifanoi) strains from the dermal lesions of an untreated and a Glucantime treated patient revealed that the treated strain is drug resistant. The activity of antimoniate of N-methyl-glucamine (Glucantime) and the ineffectiveness of sodium-stibogluconate (Pentostam) in the cutaneous L. enriettii infection of the guinea pig may depend partly on differences in the direct antileishmanial action of the drugs and on the different routes of injection. The interrelation between therapeutic action, reinnoculation, acquired immunity, relapse, drug resistance and antibody-forming capacity is discussed.

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