Angio-renographic Studies in Living Rats During the Development of Renal Cortical Necrosis

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Abstract
In oestrone-pretreated rats the administration of posterior pituitary extract (Piton) evokes renal cortical necrosis. As the changes are attributed to hypoxia the authors assumed that renal vasospasm is responsible for the renal impairment. In order to confirm this hypothesis the renal vessels of living rats pretreated with oestrone were studied with angiorenographic methods after Piton injection. The studies gave direct evidence that in oestrone-pretreated rats, following Piton administration, considerable renal vasospasm, localised on the larger renal vessels, developed. Two conclusions can be drawn from the present studies. (1) Oestrone sensitises the renal vessels to the vasoconstrictive effect of posterior pituitary extract (Piton). (2) The renal cortical necrosis observed following pretreatment with oestrone and subsequent Piton administration, is the consequence of renal vasospasm. As a result of the prolonged vasoconstriction the kidney becomes hypoxic and tubular necrosis ensues.