Antibodies to Denatured Desoxyribonucleic Acid in a Lupus Erythematosus Serum

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Abstract
Summary: The reaction between the serum of a patient with disseminated lupus erythematosus and DNA has been studied by quantitative complement fixation. Thermally denatured DNA was shown to be a more reactive antigen than native DNA. Immunologic measurement of melting out and renaturation of the antigen characterized it as DNA. DNase-digested antigen preparations failed to react but were effective inhibitors. Lupus erythematosus (LE) serum detected serologic differences in denatured DNA preparations from various sources.