Geometry of muscarinic agonists.

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Abstract
To account for a common geometric character of the skeleton of known muscarinic agonist molecules in the drug-receptor interaction, common key atoms, terminal methyl carbon, 2 oxygen and ammonium nitrogen atoms were remarked which were shown by computer calculation to be concentrated at definite points in space and to be arranged nearly in a plane. Comparison of overlapped patterns of potent agonists and weak-acting or inactive analogs drew a conclusion that the complemental receptor site have a relatively flat shape.