STUDIES ON ADRENAL INSUFFICIENCY

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Abstract
In paper V. of this series proof was given that extracts of adrenal cortex from dogs (interrenalin) can prolong the period of survival of dogs after adrenalectomy beyond the maximum seen in control untreated animals. It was stated further that similar results were obtained in dogs by intravenous injection of cortical extracts from sheep''s adrenals. The data on the influence of these extracts are given in the present paper. Subcutaneous administration of the extracts did not exert as favorable an influence as intravenous injection. Extracts prepared from the adrenal cortex of cattle in the manner recently described by Hartman and his co-workers and administered sub-cutaneously, as in their experiments, were found to have no influence on the survival period of adrenalecto-mised cats, as compared with the untreated controls. These extracts, injected intravenously into dogs, were not nearly so effective as the authors'' own extracts. If they produced any definite effect at all, it was slight. Subcutaneous administration in dogs had no favorable influence upon the survival period. Accessories were found in about 6% of 121 cats operated on for removal of the adrenals. Ulcers in the stomach or duodenum of adrenalectomised dogs and cats are very common. Of 118 adrenalectomised dogs, 48 had 1 or more ulcers. Of 89 adrenalectomised cats, 29 had ulcers. Of 32 normal cats, only 1 had a gastric ulcer.

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