SECONDARY LIPIDOSIS IN LEUKEMIA

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Abstract
Foam, cells in the spleen, bone marrow, liver and lymph nodes were examined in 73 reliably recorded and sampled leukemia autopsy cases encountered from 1958-1972. Although the substances stored in the foam cells were biochemically unknown, the foam cells in leukemia could be morphologically classified into 2 types. One was identified with the Gaucher type, but the other was not identified with the sea-blue type and might be considered a transitional type described in another report. Foam cells, could be found in the spleen of 6 of 12 cases of chronic myeloid leukemia, 1 of 2 cases of chronic lympatic leukemia, 1 of 7 cases of leukemic lymphosarcoma, 1 of 9 cases of acute lymphatic leukemia and none in 3 cases of monocytic leukemia. In acute myeloid leukemia, the incidence of foam cells in the spleen was 47.5% in 40 cases, and acquired lipidoses were more frequently seen in patients under 19 yr of age, in male cases, cases with an enlarged spleen over 400 g and cases of over 4 mo. duration.

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