Decreased Pulmonary Oxygen Toxicity by Pretreatment With Hypoxia

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Abstract
The effect of 10% or 12% oxygen pretreatment on subsequent mortality as a result of breathing 100% oxygen was studied. Rats exposed to 100% oxygen without prior treatment died after 66 ± 7 hours. Those pretreated with compressed air for 120 hours died after 61 ± 10 hours of exposure to 100% oxygen. Those pretreated with 10% oxygen for 120 hours survived exposure to 100% oxygen for 336 hours (P < .01) and were killed. Six of 16 rats pretreated with 120 hours of 12% oxygen and ten were killed after surviving 336 hours of exposure to 100% oxygen. Pretreatment of rats with 10% or 12% oxygen for 120 hours has a significant effect on subsequent survival in an environment of 100% oxygen.