CHANGES IN THE EXCRETION PATTERN OF NEUTRAL 17-KETOSTEROIDS DURING OESTROGEN ADMINISTRATION TO MALE SUBJECTS

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Abstract
SUMMARY: Changes are described in the excretion pattern of some neutral 17-ketosteroid substances during the administration of oestrogen to male subjects. The total output of 17-ketosteroids was always reduced, and the quantitative interrelationships between the individual fractions altered. The rate of excretion of androsterone was considerably reduced in all cases, and to a greater extent than that of the other fractions. The changes in etiocholanolone excretion followed the same direction but were more variable. The percentage participation of dehydroepiandrosterone was always increased, its total rate of excretion being only slightly decreased or even increased; the latter change taking place during more intensive treatment with oestrogen. The possible mechanisms involved in this response to oestrogen are discussed.