Radioiodine Uptakes in the Thyroid Studies of the Blocking and Subsequent Recovery of the Gland Following the Administration of Stable Iodine

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Abstract
In a series of experiments during 1964 small quantities of radioiodine were given to nine volunteers and their thyroid uptakes and urinary excretion patterns studied. The effects of varying doses of stable iodine on these patterns were investigated. Models of the thyroid metabolism were slightly amplified to give satisfactory explanations of the experimental results. The minimum amount of stable iodine needed to block the thyroid uptake completely was about 30 mg. Thyroid uptake ceased within half an hour of taking the blocking dose and was back to normal about 8 days after the intake. Repeated doses of stable iodine may be given at intervals to maintain effective blocking of the gland. The required doses range from 35 mg every 12 hr to 250 mg every 48 hr.