Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
Open Access
- 1 June 1990
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 29 (6) , 759-762
- https://doi.org/10.1111/j.1365-2125.1990.tb03698.x
Abstract
The effect of valproic acid (VPA) on the disposition of carbamazepine- 10,11-epoxide (epoxide) was studied in five epileptic patients on chronic carbamazepine (CBZ) therapy. The individual pharmacokinetic parameters influencing epoxide disposition were determined in the presence and absence of VPA. VPA significantly decreased the clearance of unbound epoxide (an in vivo index of epoxide hydrolase activity), but did not appear to affect epoxide formation. VPA also increased the free concentrations of both CBZ and epoxide.This publication has 14 references indexed in Scilit:
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