Aminoglycoside antibiotics. 2. N, N-Dialkylkanamycins
- 1 April 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (4) , 432-436
- https://doi.org/10.1021/jm00190a015
Abstract
N6'',N3''''-Dialkyl derivatives of kanamycins A and B were prepared regiospecifically from the parent antibiotics. Although the dimethyl and diethyl derivatives of kanamycin A were inactive in standard antibacterial assays, the dimethyl derivative of kanamycin B showed moderate activity, especially against various strains of Pseudomonas aeruginosa. A method for the selective dimethylation of the 3''''-amino group of kanamycin A also was developed.This publication has 2 references indexed in Scilit:
- Aminoglycoside antibiotics. XII. Effect of N-alkylation in kanamycin antibiotics.The Journal of Antibiotics, 1978
- Selective O-benzoylation in aminoglycoside antibiotics.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977