Tallysomycin,a new antitumor antibiotic complex related to bleomycin V. Production,characterization and antitumor activity of tallysomycin S10b,a new biosynthetic tallysomycin derivative.

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Abstract
Tallysomycin S10b is a biosynthetic derivative of tallysomycin B obtained by precursor amine-feeding fermentation. Tallysomycin S10b contains 1,4-diaminobutane as the terminal amine moiety in place of spermidine of tallysomycin B, and its assigned structure was verified by 13C NMR spectrum. The antitumor activity of tallysomycin S10b was comparable to that of tallysomycin A against Lewis lung carcinoma and B16 melanoma. Tallysomycin S10b was more active than tallysomycin A against sarcoma 180 but less active than the latter against leukemia P388. Tallysomycin S10b was less toxic than tallysomycin A in terms of acute and subacute LD50 values. The nephrotoxic potential of tallysomycin S10b in rats was less than that of tallysomycin A.