Ionisation Constants of Some Penicillins and of their Alkaline and Penicillinase Hydrolysis Products
- 1 December 1963
- journal article
- abstracts
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (Supplement) , 222T-231T
- https://doi.org/10.1111/j.2042-7158.1963.tb11216.x
Abstract
Ionisation constants of several penicillins and of 6-aminopenicillanic acid in water at 25°, and approximate ionisation constants of the products of alkaline and penicillinase hydrolysis of some penicillins, are presented. The results suggest that mild alkaline hydrolysis of benzylpenicillin is not a simple reaction. The initial product (the penicilloic acid) has the same imino-group ionisation constant as the product of penicillinase hydrolysis, but this ionisation constant decreases after further treatment with alkali. The nature of this effect is discussed.Keywords
This publication has 13 references indexed in Scilit:
- The Estimation of Penicillins and Penicillin DestructionJournal of Pharmacy and Pharmacology, 1963
- 6-Aminopenicillanic acid III. Isolation and purificationProceedings of the Royal Society of London. B. Biological Sciences, 1961
- Formation of D-Penicillamine-Cysteine Mixed Disulphide by Reaction of D-Benzylpenicilloic Acid with CystineNature, 1960
- A Simple Method for the Production of High Titre PenicillinaseJournal of Pharmacy and Pharmacology, 1957
- The chemistry of the penicillinsQuarterly Reviews, Chemical Society, 1948
- Review of chemical methods for the determination of penicillinAnalytica Chimica Acta, 1947
- ELECTRON SHARING ABILITY OF ORGANIC RADICALS. VI. ALPHA-SUBSTITUTED PYRROLINES AND PYRROLIDINESJournal of the American Chemical Society, 1932
- ZwitterionsBiochemical Journal, 1930
- The titration of amino- and carboxyl-groups in amino-acids, polypeptides, etc. Parts I—III.—Investigations with aqueous solutionsProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1923
- A DIAGRAMMATIC REPRESENTATION OF EQUILIBRIA BETWEEN ACIDS AND BASES IN SOLUTION.Journal of the American Chemical Society, 1908