Action de quelques phénothiazines et iminodibenzyles sur la division cellulaire et sur certains processus de croissance

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Abstract
The phenthiazines and iminodibenzyles examined slow down considerably the cell-division of fertilized eggs of echinidae and of ranidae; chlor-promazine acts more strongly than Tofranil. The same products clearly inhibit the phenomena of regeneration in planarians and in axolotl; chlorpromazine is more effective than Tofranil. They stop granulation and exudation of an inflammatory granuloma of a rat; here, too, chlorpromazine is more effective than Tofranil. In the solid form of ascitic tumor of EHRLICH in mice, these properties which inhibit proliferation do not correspond to the inhibition of growth produced by subcutaneous injection of drugs in various doses. Moreover, these products, and chlorpromazine in particular, tend to some extent to have an inhibitory effect on the liquid form of this tumor.