Aucubin: Potential Antidote For Alpha-Amanitin Poisoning
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology: Clinical Toxicology
- Vol. 22 (1) , 77-85
- https://doi.org/10.3109/00099308409035083
Abstract
Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50 % survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.This publication has 17 references indexed in Scilit:
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