Radioiodine Treatment of Thyrotoxicosis: A Single Dose Method Following a Drug Preparation

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Abstract
1. Thirty-two thyrotoxic patients were treated with radioiodine by a single dose procedure after drug preparation with thiouracil and thyroxine; at a one-year follow-up, 26 had remitted, 5 had needed re-treatment and 1 had permanent myxoedema. 2. This clinical response could be related to the estimated mean radiation received by the thyroid calculated in “radiation dose units”. This depended partly on the planned dose given (100, 150 or 250 μc/g thyroid at 48 hours) and partly on the effective half-life of the iodine in the thyroid. 3. The thyroid glands of those patients given a routine drug preparation with thiouracil and thyroxine retained the iodine longer (biological half-life 27·8 days) than those given an atypical drug preparation (biological half-life 10·6 days). 4. The clinical management of the radioiodine treatment of thyrotoxicosis has been simplified by a drug preparation. It can be so planned that a single dose will frequently suffice.

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