Abstract
Chronic middle-ear disease may result directly from secretory otitis in childhood. This is based on an analysis of different materials, including healthy children in various age groups who were followed by tympanometry over a long period of time; children with secretory otitis who were re-evaluated 3-8 yr after treatment, with special reference to changes in the tympanic membrane; and an otosurgical group comprising 1100 ears, which were re-evaluated 3-14 yr after operation. Chronic secretory otitis and chronic tubal dysfunction, which are particularly frequent in childhood, may cause such changes in the tympanic membrane and/or middle ear, that conditions are created which later on, maybe years after remission of secretory otitis, may favor the development of cholesteatoma, non-cholesteatomatous chronic otitis and perforation of the tympanic membrane.

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