Effect of atropine on the latency of cochlear potentials.

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Abstract
The effect of atropine administered intravenously and by round window diffusion on the latency of the cochlear potentials was tested in anesthetized guinea pigs. Administration by both routes caused a prolongation of the latency of the nerve action potential but did not affect the latency of the cochlear micrpphonic. Atropine must interfere with synaptic transmission in the cochlea or the generation and conduction of nerve impulses up the fibers of the auditory nerve. From an analysis of 6 possible ways by which this effect might be mediated, atropine either blocks afferent synaptic transmission directly or interferes with a possible facilitatory influence of the adrenergic innervation of the cochlea on nerve impulse generation.

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