Genetic Control of Chloroform Toxicity in Mice
- 10 October 1975
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4210) , 159-161
- https://doi.org/10.1126/science.1166306
Abstract
Mouse strain differences suggest intermediate or multifactorial gentic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.This publication has 35 references indexed in Scilit:
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