Synthesis of analogues of 5-iodo-2′-deoxyuridine-5′-diphosphate
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 17,p. 2197-2202
- https://doi.org/10.1039/p19920002197
Abstract
The synthesis of three types of diphosphate analogues of 5-iodo-2′-deoxyuridine-5′-diphosphate is reported. Routes are described to the 5′-phosphonoacetamido, the 5′-N-phosphonosulfamoyl and the 5′-O-sulfamoylcarbamoyl derivatives, 2, 3 and 4 starting from 5-iodo-2′-deoxyuridine (IDU). In the course of the synthesis of 3, the 5′-sulfamoyl derivative 19, an analogue of IDU 5′-monophosphate was prepared. The antiherpes virus activity of 2, 4 and 19 is reported.Keywords
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