Development of Resistance by Cell Cultures to Photodynamic Action

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Abstract
Unexpected degeneration of uppermost layer of cell cultures was shown to be caused by sensitization of cells by neutral red to damage by light i.e., photodynamic action. Sensitization of cells by neutral red was shown to increase to a maximum at 1 hour. Loss of sensitization began at 8 hours and cells were completely resistant to light at 24 hours. The results indicate that loss of sensitization was probably due to a change in cells rather than alteration of absorbed neutral red.