Strain and Sex Differences in Response of Inbred Mice to Adrenal Cortical Hormones

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Abstract
Eosinopenic responses of adrenalectomized male mice of 9 inbred strains to injd. cortisone fell into 2 groups. Sensitive strains (C57BL/6, C57BR/cd, C57BR/a, BBF1, F1 129 X C57BR/cd) responded significantly to 1 [mu]g- and maximally to 6 [mu]g. cortisone. Insensitive strains (129/Rr, DBA/1, BALB/c, Street) required 3-6 ug. for a significant response and 96 [mu]g. to approach max. eosinopenia. Use of an inbred strain in the bioassay of corticoids reduces genetic variability in response, and number of control animals necessary. A sensitive strain may detect physiological amts. of hormone, thus eliminating error inherent in concn. processes.