PERMISSIVITY OF MOUSE-MAN HYBRID CELL CLONES TO 3 ENTEROVIRUSES - POLIOVIRUS II, COXSACKIE B3 AND ECHOVIRUS 11 - ROLE OF HUMAN CHROMOSOME F-19

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 24  (3) , 195-203
Abstract
The permissivity of human cells to enteroviruses is linked to the presence of specific cell receptors. Owing to the chance elimination of human chromosomes, the man-mouse hybrid cells may be permissive or not depending on whether the genome responsible for synthesis of the receptors is conserved. By comparison of the cytopathogenic effects and virus production after inoculation of the polio II, Echo 11 and Coxsackie B3 viruses into various hybrid strains, an identity of the spectrum of permissivity to these 3 viruses was observed. An enzyme study revealed a very high correlation between this permissivity and clone expression of human glucose phosphate isomerase, whose structural gene was located on chromosme F 19. The presence on this chromosome of a gene(s) governing the synthesis of specific cell receptors to the viruses studied is suggested.