Loss of Hextuple Resistance to Aminoglycoside Antibiotics in Mycobacterium tuberculosis (H37RV) by Mutation to Isoniazid Resistance and by Incubation at High Temperature

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Abstract
Hextuply-resistant M. tuberculosis mutants (6R mutants) are resistant to high concentrations of 6 aminoglycoside antibiotics, emviomycin, viomycin, capreomycin, kanamycin, lividomycin and paromomycin. The 6R mutants lost their resistance after mutation to isoniazid resistance and on incubation at 45.degree. C. The mutation to isoniazid resistance involves a deletion in the genome and occurs without re-organization or synthesis of enzymes, and this deletion is accompanied by deletion of other genes.