THE DISTRIBUTION OF CHLORMERODRIN (NEOHYDRIN®) IN TISSUES OF THE RAT AND DOG 1

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Abstract
When chlormerodrin (Neohydrin) was given intramuscularly to rats in a dose of 1 mg of Hg/kg, 80% of the dose accumulated in the 2 kidneys within 6 hours at a concentration of 100 [mu]g of Hg/g of tissue. Excretion was slow; only 21% of the dose was eliminated in 24 hours. No other tissue bound Hg in a concentration even vaguely approaching that of the kidney. Increasing the dose of chlormerodrin from 0.1 to 10 [mu]g of Hg/kg failed to saturate the renal mechanism which binds Hg- Dithio-propanol given at the same time as chlormerodrin reduced the renal binding, augmented diffusibility and increased the excretion of the diuretic. The dog differs from the rat mainly in excreting the diuretic much more rapidly.