Iodoacetamide Induced Gastric Ulcers in Rats.

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Abstract
Experimental production of gastric ulcers in animals with cortisone, histamine, cincophen or reserpine is frequently complicated by undesirable side reactions. These chemicals may cause gastric perforation or rapid weight loss. In this study it was possible to produce ulceration of the secretory gastric mucosa without emaciation or gastric perforation by feeding ipdoacetamide in drinking water. Concentrations of 50 or l00mg of iodoacetamide per 100ml of water did not inhibit growth of immature rats. The rats were fed up to 93 days without evidence of appreciable toxicity. In contrast to observations made in stomachs from control rats, iodoacetamide feeding produced chronic gastric ulceration in 9 of 17 test rats. Due to the apparent good health and sustained weight gain in the test rats it is believed that the production of ulcers in this manner may provide a useful tool for future investigation.

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