Compatibility System Controlling Heterokaryon Formation in Streptomyces coelicolor.

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Abstract
Summary Heretofore, complementary pairs of growth-factor dependent mutants of Streptomyces coelicolor have interacted to yield colonies which grow readily in the absence of added supplements. Recently however certain combinations have been found which did not interact successfully. This failure of nutritionally dependent mutants to form growth-factor independent growth was not the result of allelism, but of a compatibility system controlling heterokaryon formation. The compatibility system was apparently determined by two factors, one of which probably arose by mutation.
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