Gastric blood flow and secretion in conscious dogs

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Abstract
The relationship between gastric blood flow and secretion was studied in conscious dogs. Administration of either extracted porcine gastrin or a related, synthetic pentapeptide, each in a wide range of increasing doses, caused a progressive rise in secretory rate from Hei-denhain pouches. Following gastrin stimulation mucosal blood flow, determined by the clearance of aminopyrlne, increased as secretory rate increased, except at the highest rates of secretion. Stimulation with pentapeptide was followed by parallel increases in mucosal blood flow and secretory rate over the entire secretory range. Total blood flow, measured by an electromagnetic blood flowmeter chronically implanted on the artery supplying the pouch, was not altered by either stimulant of gastric secretion. Stimulation of dogs with gastric fistulas by either insulin or 2-deoxy-D-glucose increased secretory rate, mucosal blood flow, and arterial inflow. All three measurements were reduced by atropine and by an anesthetizing dose of pentobarbital.