Enantioselective Construction of Quaternary Stereocenters
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- 17 December 2001
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 40 (24) , 4591-4597
- https://doi.org/10.1002/1521-3773(20011217)40:24<4591::aid-anie4591>3.0.co;2-v
Abstract
The stereoselective formation of C−C bonds is of great importance for the synthesis of enantiomerically pure natural products and pharmaceuticals. A broad repertoire of chiral auxiliaries, reagents, and catalysts can be utilized for the reliable generation of tertiary stereocenters. In contrast, the synthesis of organic compounds with quaternary stereocenters is a much more demanding and challenging task. Every enantioselective synthetic method can demonstrate its value through the generation of a fully substituted carbon center. In this Minireview examples of newer stoichiometric and catalytic methods are summarized which have proved their suitability for the enantioselective construction of quaternary stereocenters.Keywords
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