Exercise, hypophysectomy, and spleen weight.

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Abstract
The immediate and delayed effects of exercise upon the weight and the ratio (spleen weight/body weight) of the spleen were investigated in normal, hypophysectomized, hypophysectomized + growth hormone, vagotomized, immunological sympathectomized, and diencephalon-lesioned male rats. Spleen weights and ratios from animals immediately exercised were significantly lower than non-exercised controls. With the exception of the hypophysectomized runners, training had no appreciable influence on these measures. When normal and hypophysectomized animals received exogenous bovine growth hormone it was observed that the weight of the spleen was associated with the dosage injected. The hypothesis was presented that the absence of the restorative influences from the growth hormone was responsible for the lower weights and ratios associated with the trained hypophysectomized runners.

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