Synthesis and antiallergic properties of some 4H,5H-pyrano[3,2-c][1]benzopyran-4-one, 4H,5H-[1]benzothiopyrano[4,3-b]pyran-4-one, and 1,4-dihydro-5H-[1]benzothiopyrano[4,3-b]pyridin-4-one derivatives
- 1 December 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (12) , 1372-1376
- https://doi.org/10.1021/jm00186a016
Abstract
A series of novel 2-carboxylic acids of the title ring systems was synthesized from the corresponding 3-acetyl-4H-[1]benzopyran-4-one and benzothiopyran-4-one. These acids were examined for their ability to inhibit the rat passive cutaneous anaphylaxis; the pyridinone carboxylic acids displayed a higher degree of i.v. and i.p. anaphylactic activities than their pyranone analogs 5. The potassium salt 5a (R6 = K) was the only compound that exhibited a moderate oral activity.This publication has 10 references indexed in Scilit:
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