Anthelmintic Studies with Pyrantel. I. Therapeutic and Prophylactic Efficacy against the Enteral Stages of Various Helminths in Mice and Dogs

Publisher Website
Google Scholar
Abstract
Pyrantel tartrate was evaluated as a therapeutic and prophylactic anthelmintic against intestinal parasites representing 3 nematode suborders (Strongylata, Ascaridata, Trichurata) and one cestode order (Cyclophyllidea). Therapeutic studies in mice showed 12.5 mg/kg and 25 mg/kg to be the minimum effective dose against Nematospiroides dubius and Nippostrongylus brasiliensis, respectively. When incorporated in feed at the 0.01% level, and administered ad lib. to parasitized mice for 7 days, N. dubius. N. brasiliensis, and Syphacia obvelata burdens were all reduced at least 90%. Hvmenolepis nana burdens were unaffected. The same concentration was also prophylactic, against the 3 nematode species, when administered 7 to 14 days, commencing the day of infection. A dose of 50 mg/kg, administered to mice 2 hr. after the oral inoculation of Trichinella spiralis larvae, resulted in an average reduction of 91.6% in the adult nematode burdens which established. A dose of 20 mg/kg produced a 72.2% reduction. When incorporated in feed for 3 days, commencing 24 hr. before the inoculation of larvae, 0.5, 0.2, and 0.1% pyrantel tartrate caused 98, 96.7, and 38.6% reductions, respectively. Therapeutic studies in dogs showed that 5 mg/kg and 2.5 mg/kg are the minimum effective doses against ascarids and hookworms, respectively. No significant activity was detected against Trichuris vulpis. Taenia pisiformis, or Dipylidum caninum.