Genealogical trees, coalescent theory and the analysis of genetic polymorphisms
Top Cited Papers
- 1 May 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 3 (5) , 380-390
- https://doi.org/10.1038/nrg795
Abstract
Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.Keywords
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