Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes
- 1 May 2004
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 21 (5) , 785-792
- https://doi.org/10.1023/b:pham.0000026429.12114.7d
Abstract
Purpose. To compare three liver models (well-stirred, parallel tube, and dispersion) for the prediction of in vivo intrinsic clearance (CLint), hepatic clearance (CLh), and hepatic availability (Fh)...Keywords
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