Structure-activity relationship of a novel antitumor ansamycin antibiotic trienomycin A and related compounds.
- 1 January 1988
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 41 (9) , 1223-1230
- https://doi.org/10.7164/antibiotics.41.1223
Abstract
Various derivatives of trienomycin A (1) were prepared and tested for cytocidal activities. All the derivatives except for 22-O-mehtyltrienomycin A (5) showed reduced cytotoxicity compared with 1. It is concluded that the existence of a triene moiety, free 13-OH and an acyl group at C-11 owe important role for cytocidal activity.This publication has 5 references indexed in Scilit:
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