ANTIBODY SYNTHESIS BY TRANSFERRED LYMPHOID CELLS: THE INFLUENCE OF THE HOST GENETIC ENVIRONMENT ON THE DURATION OF THE IMMUNE RESPONSE

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Abstract
SUMMARY Spleen cells from 129/JaxHe and C3H/He mice, actively immunized with bovine serum albumin, were transferred to 129/ JaxHe, C3H/He, and F1 hybrids of these strains. Grafts of spleen cells from the two strains showed similar patterns of behavior, in that the antibody to bovine serum albumin was detectable for at least 60 days in syngenie recipients when male spleen cells were transferred to male recipients. Females accepted male cells transiently; antibody rarely was present at the 4th week. Parental spleen cells produced antibody for limited periods of 1 month in F1 mice. The two mouse strains differed in their responsiveness to certain grafts of skin. Female 129 mice rejected male 129 skin grafts, whereas C3H females appeared to accept grafts of C3H male skin. Such grafted C3H females, however, had an impaired ability to support the functioning of male immune spleen cells. Grafts of lymphoid cells, therefore, provided sensitive indicators of minor degrees of tissue incompatibility.