Topical effects of 16,16-dimethyl prostaglandin E2 on gastric blood flow in dogs

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Abstract
The effects of luminal instillation of 16,16-dimethyl prostaglandin E2 (dmPGE2) on total gastric blood flow and its fractional distribution between the layers of gastric tissue were determined in exteriorized segments of the greater curvature of dog stomach. Total gastric blood flow was measured simultaneously by venous outflow and .alpha.-labeled microspheres; both methods correlated well with each other (correlation coefficient = 0.88, P < 0.01). In the nonstimulated stomach, dmPGE2 caused an increase in total gastric blood flow from 4.2 .+-. 0.8 to 7.4 .+-. 1.2 ml/min (P < 0.05). In contrast, dmPGE2 significantly reduced gastric blood flow in histamine-stimulated stomach (from 14.6 .+-. 1.2 to 9.2 .+-. 1.0 ml/min; P < 0.01). The changes in mucosal blood flow were proportional to the alterations in total blood flow because the fractional distribution of blood flow to the mucosa remained relatively unchanged during dmPGE2 administration. dmPGE2, a known vasodilator, apparently induces an increase in gastric blood flow in the resting stomach, whereas it reduces gastric blood flow in the actively secreting stomach as a result of secretory inhibition.