Pharmacokinetics of viloxazine hydrochloride in man

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Abstract
The pharmacokinetic characteristics of a new antidepressant, viloxazine hydrochloride, were investigated in five males and five females to study sex differences. Plasma levels were determined over a period of 9 h after a single dose of viloxazine of 100 mg (expressed as base). The half life of the drug was in the range of 2.19–4.21 for females and 2.61–4.31 h for males. The maximum plasma levels occured in 29–171 min of the oral dose for females and 54–155 min formales. They reached 1382–1769 ng/ml-1 for females and 1108–2932 ng/ml-1 for males. Pharmacokinetic data were not statistically different between males and females.