The effect of metrazol on the susceptibility of rats to sound-induced seizures.

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Abstract
An exptl. group of 24 rats was tested 5 days a wk. for sound-induced seizures over a 3-wk. period. During the tests of the 2nd wk. a sub-convulsive dose of metrazol was administered intra-perit. to 12 animals prior to exposure to sound. Such treatment prior to testing was omitted during the 1st and 3d wks. Sterile water was substituted for the metrazol in the other 12 animals. A marked increase in incidence of seizures was observed in the first group during the 2nd wk. No such change in susceptibility was noted in the 2d group. It is tentatively concluded that the effect of metrazol was to alter temporarily the psychological condition of the animal so as to render it more susceptible to sound-induced seizures.

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